A new tetrahydrofuran lignan from Peperomia blanda / 国际药学研究杂志

ABSTRACT

Objective To investigate the chemical constituents of Peperomia blanda. Methods Guided by HPLC detec?tion,integrated methods including vacuum liquid chromatography(VLC),ODS and semi-preparative RP-HPLC were used for separa?tion. The structure was determined by spectral analyses including ESI-MS,1D NMR,2D NMR and ECD spectra. Results Four com?pounds were isolated and identified as(7S,7′S,8R,8′R)-7-(5-methoxy-3,4-methylenedioxyphenyl)-7′-(4-hydroxy-3,5-dimethoxy?phenyl)-8,8′-dihydroxymethyltetrahydrofuran(1),7,8-trans-8,8′-trans-7′,8′-cis-7,7′-(4-hydroxy-3,5-dimethoxy phenyl)-8,8′-di?acetoxymethyltetrahydrofuran(2),(+)-(7S,7′S,8R,8′R)-4,4′-dihydroxy-3,3′,5,5′-tetramethoxy-7,9′,7′,9-diepoxylignane(3), and(6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one(4). Conclusion Compound 1 is a new tetrahydrofuran lignan,compounds 2-4 were isolated from P. blanda for the first time.