Effect of lipid and surfactant digestion on poorly water-soluble drug solubilization and absorption in gastrointestinal tract using self-emulsifying drug delivery systems / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 899-904, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-503966
ABSTRACT
Self-emulsifying drug delivery systems(SEDDS)are a vital tool in solving low oral bioavailability of poorly soluble drugs(PWSD). SEDDS may improve oral absorption via several mechanisms,however,enhancement of gastrointestinal solubilization of PWSD remains the most important factor of absorption enhancement. This review introduces the methods including dispersion tests and lipolysis tests in vitro as the indicators of potential performance in vivo. The use of these methods in vitro combined with oral bio?availability study is subsequently described,with particular focus on recent data which suggest that the digestion of lipid and surfac?tants present in SEDDS formulations impact on formulation performance in vivo. This review is expected to provide some guiding princi?ples on formulation design of SEDDS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS