Effect of propofol on the patients under neurally adjusted ventilator assist / 中华急诊医学杂志

ABSTRACT

Objective To investigate the effects of different depths of propofol sedation on patients under neurally adjusted ventilator assist (NAVA)ventilation.Methods A total of fifty patients supported by NAVA ventilation admitted from June 2012 to June 2015 into intensive care unit (ICU)were enrolled for prospective study.The patients were randomly divided into light sedation group (n =20)and deep sedation group (n =20).The respiratory mechanics indexpeak inspiration pressure (PIP),mean airway pressure (Pmean),electrical activity of the diaphragm (EAdi),gas exchange index,pH value of arterial blood, partial pressure of oxygen (PaO2 ), partial pressure of carbon dioxide (PaCO2 ), patient-ventilator synchrony,trigger delay time,off cycle delay time,hemodynamic indexes,mean arterial blood pressure (MAP),heart rate (HR)of the two groups were detected and documented.Enumeration data were analyzed with χ2 test,measurement data were analyzed with t test,and P 0.05 ),while under the deep sedation,MAP and HR were lower than those in wakefulness and under light sedation (compared with wakefulness,the t values of deep sedation respectively were 2.805,2.944,and compared with light sedation,the t values of deep sedation were significantly reduced to 2.175,2.019,respectively,P 0.05 ).Conclusions Light sedation of propofol could reduce the EAdi and airway pressure without effect on gas exchange,haemodynamics and patient-ventilator synchrony in the patients under NAVA ventilation.