Protective Effect of Different Extraction Samples from Salvia miltiorrhiza Decoction against Acute Myocar-dial Ischemia Model Mice / 中国药房
China Pharmacy
;
(12): 913-915, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-504325
ABSTRACT
OBJECTIVE:
To observe the protective effect of different extraction samples from Salvia miltiorrhiza decoction on acute myocardial ischemia model mice.METHODS:
96 mice were randomized into blank control group (normal saline),model group(normal saline),positive drug group [Compound Salvia miltiorrhiza tablet,4.6 mg(crude drug)/(kg·d)],high-dose,medi-um-dose and low-dose groups of water extract,supercritical CO2 extract and supercritical CO2 extract+dregs water extract [24,12, 6 mg(crude drug)/(kg·d)],with 8 mice in each group,12 groups in total. They were given medicine intragastrically once a day. On sixth day,30 min after giving drugs,those groups were given isoprenaline 20 mg/kg,ih,to induce myocardial ischemia model except for blank control group,once a day,for consecutive 3 d. Electrocardiogram ST segment variation of mice were observed. The times and duration of buccal respiration were observed after rapid decapitation,and the activities of CK and LDH in serum were determined.RESULTS:
Compared with blank control group,electrocardiogram ST segment and the activity of CK and LDH increased in model group,while the times and duration of buccal respiration after rapid decapitation reduced(P<0.01);compared with model group,above indicators of medication groups had been improved (P<0.01),and were positively correlated to drug concentration;the indicators of supercritical CO2 extract+dregs water extract group were most close to those of blank control group.CONCLUSIONS:
Different extraction samples from Saliva miltiorrhiza decoction all have protective effect on acute myocardial ischemia model mice,and the protective effect of supercritical CO2 extracting+dregs water extracting sample of Salvia Miltiorrhiza decoction is best.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS