miR-150 deletion affects breeding and hematologic parameters of mice / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 1409-1412, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-504362
ABSTRACT
Objective:
To investigate the effect of miR-150 gene deletion on the breeding and hematologic parameters of mice.Methods:
The nest litter size,wean rate and weight changes of miR-150 knock out (miR-150ko) and C57BL/6J mice were com-pared. The hematology indexes were analyzed by automated blood cell counter, the serum biochemical parameters were analyzed by automatic biochemical analyzer.Results:
The nest litter size and wean rate of miR-150ko mice were significantly decreased compared with that of C57BL/6J mice. The number of total white blood cells,intermediate cells,neutrophils,and the percentage of neutrophils and intermediate cells were significantly increased in miR-150ko mice compared with that of C57BL/6J mice. However,the number and per-centage of platelets and lymphocytes decreased significantly in miR-150ko mice. In addition,the levels of serum glucose and TC were in-creased significantly in miR-150ko mice compared with that of C57BL/6J mice.Conclusion:
miR-150 gene deletion impairs the breeding and has complex impact on hematologic parameters of mice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2016
Type:
Article
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