Preparation of Genistein Solid Dispersion and Its Properties Study / 中国药房
China Pharmacy
;
(12): 1406-1408, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-504398
ABSTRACT
OBJECTIVE:
To prepare Geinstein (GEN) solid dispersion,and improve the dissolution rate of GEN in vitro.METHODS:
Using PVP K30,PEG6000,and PEG4000 as carriers,GEN solid dispersion was prepared by solvent melting meth-od,and its dissolution in vitro was investigated. The structure of the solid dispersion was characterized by FTIR and DSC. RE-SULTSGEN solid dispersion prepared with PEG4000 as carrier was better than those with other carriers in dissolution,and drug-carrier ratio (15) was the best. The results of DSC and FTIR showed that GEN in solid dispersion took amorphous form.CONCLUSIONS:
GEN solid dispersion is prepared successfully and significantly improve the dissolution of GEN in vitro.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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