Effects of Atorvastatin Combined with Valsartan on Efficacy and Related Indicators in Patients with Chronic Nephritis / 中国药房
China Pharmacy
;
(12): 2065-2067, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-504458
ABSTRACT
OBJECTIVE:
To investigate the effects of atorvastatin combined with valsartan on efficacy,safety and related indi-cators in patients with chronic nephritis.METHODS:
86 patients with chronic nephritis were randomly divided into control group (43 cases)and observation group(43 cases). All patients were given low-salt,low-protein and high-quality diet with protein intake of 0.8 g/(kg·d),appropriately given Cyclophosphamide tablet,Prednisone tablet,Penicillin V potassium tablet and other conven-tional treatment. Based on it,control group was given 160 mg valsartan,once a day in early morning. Observation group was addi-tionally given 20 mg atorvastatin,once a day before bedtime. They were treated for 6 months. Clinical efficacy,24 h protein amount (24 h pro),serum creatinine (Scr),blood urea nitrogen (BUN),glomerular filtration rate (GFR),C-reactive protein (CRP),total cholesterol (TC),triglyceride (TG ),low density lipoprotein (LDL) and high density lipoprotein (HDL) in 2 groups were observed,and incidence of adverse reactions was followed-up for 9 months.RESULTS:
The total effective rate in ob-servation group was significantly higher than control group,the difference was statistically significant(P0.05). After treatment,24 h pro,Scr,BUN and CRP in 2 groups were significantly lower than before,and observation group was lower than control group,GFR was significantly higher than before,and observation group was higher than control group,the differenc-es were statistically significant(P0.05). And there was no significant differences in the incidence of adverse reactions between 2 groups (P>0.05).CONCLUSIONS:
Based on the conventional treatment,the efficacy of atorvastatin combined with valsartan is superior to valsartan alone in the treatment of chronic nephritis,and it can significantly improve renal functions,with similar short-term safety.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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