Progress in microRNA in osteosarcoma / 肿瘤研究与临床

ABSTRACT

Osteosarcoma is a primary malignant bone tumor with high invasiveness and metastasis that occurs mainly in children and adolescents. The pathogenesis of osteosarcoma remains unclear. MicroRNAs (miRNAs), a class of nucleotides non-coding RNAs, can regulate gene expression at the post-transcriptional level through binding to target mRNAs. Besides, MiRNAs takes control of many important pathophysiological processes in molecular level, including the initiation and invasiveness of osteosarcoma.This review summarizes the roles of miRNAs in initiation,development,transformation and chemoresistance of osteosarcoma to bring new ideas for both pathogenesis exploration and targeted therapy of osteosarcoma.