Relationship between WT1 gene polymorphism rs16754 and prognosis of acute myeloid leukemia:a meta-analysis / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 543-548, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-504650
ABSTRACT
Objective To analyze the relationship between WT1 gene polymorphism rs16754 and prognosis of acute myeloid leukemia (AML) by meta-analysis. Methods Studies published in PubMed, CNKI, WanFang and CBM database were searched by using the search terms 'WT1', 'Polymorphism' and 'Leukemia, Myeloid, Acute', respectively. Deadline was December 1, 2015. Results A total of 11 English articles with a total of 2 789 patients were included. Meta-analysis showed that there was no association between polymorphism rs16754 and complete remission of AML patients (RR=1.02, 95 % CI 0.99~1.06, P=0.20), overall survival(OS) (HR=0.68, 95 % CI 0.45~1.02, P=0.06), 5-year OS (RR=1.10, 95 % CI0.90~1.34, P=0.37) or relapse-free survival (RFS) (HR=0.80, 95 % CI 0.54~1.19, P=0.27). Conclusion There is no correlation between WT1 gene polymorphism rs16754 and the prognosis of AML.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Systematic reviews
Language:
Chinese
Journal:
Journal of Leukemia & Lymphoma
Year:
2016
Type:
Article
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