Clinical Observation of Medroxyprogesterone or Dydrogesterone Combined with Hysteroscopic Electrosur-gery in the Treatment of Early Estrogen-dependent Endometrial Cancer / 中国药房
China Pharmacy
;
(12): 2910-2912, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-504716
ABSTRACT
OBJECTIVE:
To compare the efficacy and safety of medroxyprogesterone or dydrogesterone combined with hystero-scopic electrosurgery in the treatment of early estrogen-dependent endometrial cancer.METHODS:
42 patients with early estro-gen-dependent endometrial cancer were randomly divided into medroxyprogesterone group (21 cases) and dydrogesterone group (21 cases). All patients received hysteroscopic electrosurgery. Medroxyprogesterone group received 100 mg Medroxyprogesterone acetate tablet,3 times a day. Dydrogesterone group received 100 mg Dydrogesterone tablet,twice a day. The treatment course for both groups was 6 months. Clinical efficacy,carbohydrate antigen CA125(CA125),body mass and the incidence of adverse reac-tions in 2 groups were observed.RESULTS:
After 3 months of treatment,the total effective rate in dydrogesterone group was sig-nificantly lower than medroxyprogesterone group,the difference was statistically significant(P0.05). Before treatment,there were no significant differences in CA125 and body mass in 2 groups (P>0.05). After 3 and 12 months,CA125 levels in 2 groups were significantly lower than before,12 months was lower than 3 months,and dydrogesterone group was higher than medroxyprogesterone group after 3 months,the differ-ences were statistically significant (P0.05). After treatment,the body mass in medroxyprogesterone group was significantly higher than before,the difference was statis-tically significant (P0.05). And the incidence of adverse reactions in dydrogesterone group was significantly lower than medroxyprogesterone group,the difference was statistically significant(P<0.05).CONCLUSIONS:
The short-term efficacy of medroxyprogesterone combined with hysteroscopic electrosurgery is superior to dydrogesterone combined with hysteroscopic electrosurgery in the treatment of early estro-gen-dependent endometrial cancer,but medroxyprogesterone combined with hysteroscopic electrosurgery shows high incidence of adverse reactions. Long-term effects of both Dydrogesterone and Medroxyprogesterone are equivalent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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