Study on Preparation and in vitro Dissolution of Ethyl Pepper Solid Dispersion / 中国药房
China Pharmacy
;
(12): 3132-3135, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-504850
ABSTRACT
OBJECTIVE:
To study the preparation and in vitro dissolution of ethyl pepper solid dispersion.METHODS:
Sol-vent-melting method was adopted. Using polyethylene glycol 6000(PEG-6000)as carrier,the effects of different drug-loading ratios (1∶1,1∶5,1∶7,1∶10,1∶15,1∶18,1∶20)on the dissolution of ethyl pepper solid dispersion was invesigated. The stability of crude drug ethyl pepper at 85℃was determined. Furthermore,differential scanning calorimetry and X-ray powder diffraction meth-od were used to identify the existence of ethyl pepper in the solid dispersion.RESULTS:
The dissolution of ethyl pepper could be improved by mixing ethyl pepper and PEG-6000 in a ratio of 1∶15,and the preparation was maintained stable at 85 ℃. The drugs part of ethyl pepper-PEG-6000 solid dispersions existed in the form of amorphous or molecular.CONCLUSIONS:
The dissolution of ethyl pepper solid dispersion can be improved significantly by mixing ethyl pepper and PEG-6000 (1∶15),and the dispersion keeps stable at 85℃. The study can provide reference for further study of the preparation technology of ethyl pepper preparation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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