Preparation of Levofloxacin and Triamcinolone Acetonide Double-loaded Ophthalmic Gel / 中国药房
China Pharmacy
;
(12): 3125-3127, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-504873
ABSTRACT
OBJECTIVE:
To prepare Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel.METHODS:
Us-ing levofloxacin hydrochloride and triamcinolone acetonide as main components,carbopol-940P as base material,HPMC K4M as tackifier,Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel was prepared. Using dissolution time as index, the contents of carbopol-940P and HPMC K4M were determined by single factor test,and dissolution time,viscosity and the con-tents of 2 main components were also determined.RESULTS:
The concentrations of carbopol-940P and HPMC K4M were 0.4%and 1.2%,separately. The dissolution time was more than 24 h and viscosity was 1 142.67 Pa·s. The content of levofloxacin hydro-chloride was 97.3% of labelled amount (RSD=0.84%,n=3),and that of triamcinolone acetonide was 92.97% of labelled amount(RSD=1.32%,n=3).CONCLUSIONS:
Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel has been prepared successfully.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS