Effectiveness and Safety of Combination Prescription of Lidocaine with Ropivacaine for Anesthesia:A Sys-tematic Review / 中国药房

ABSTRACT

OBJECTIVE:To systematically review the effectiveness and safety of combination prescription of lidocaine with ropivacaine for anesthesia,and provide evidence-based reference for developing new compound preparation. METHODS:Retrieved from CJFD,Wanfang Database,VIP,PubMed and EBSCO,randomized controlled trials (RCT) about lidocaine combined with ropivacaine versus lidocaine alone or ropivacaine alone for anesthesia were collected. Meta-analysis was performed by using Rev Man 5.0 software provided by the Cochrane Collaboration after data extracting and quality evaluating. RESULTS:Totally 30 RCT were included,involving 2 442 patients. Results of Meta-analysis showed,lidocaine+ropivacaine vs. lidocaineonset time was 6.77 min vs. 7.11 min [MD=-0.29,95%CI(-0.43,-0.16),P<0.001],maintenance time was 5.11 h vs. 2.11 h [MD=3.13,95%CI (3.02,3.25),P<0.001] and the incidence of adverse reactions was 28.6% vs. 44.6% [MD=0.43,95%CI(0.31,0.62),P<0.001];lidocaine+ropivacaine vs. ropivacaineonset time was 9.49 min vs. 15.85 min [MD=-4.43,95%CI(-4.63,-4.22),P<0.001];maintenance time was 4.84 h vs. 6.79 h [MD=-0.61,95%CI(-0.71,-0.51),P<0.001];the incidence of adverse reac-tions was 44.8% vs. 48.1% [MD=0.82,95%CI(0.56,1.19),P=0.30]. Sensitivity analysis showed that the results were in stabili-ty. CONCLUSIONS:Lidocaine combined with ropivacaine shows rapid onset and long duration in anesthesia,and it can reduce ad-verse reactions play their respective advantages.