Decreased Pattern-Recognition Receptor-Mediated Cytokine mRNA Expression in Obese Children With Otitis Media With Effusion
Clinical and Experimental Otorhinolaryngology
;
: 7-12, 2014.
Article
in English
| WPRIM
| ID: wpr-50496
ABSTRACT
OBJECTIVES:
To assess innate and humoral immune responses in middle ear effusion of obese pediatric patients with otitis media with effusion (OME).METHODS:
We evaluated 219 children with OME, of whom 21 were obese and 198 were non-obese. We compared the expression in middle ear effusion of mRNAs encoding toll-like receptors (TLR) 2, 4, 5, and 9; nucleotide-binding oligomerization domains (NOD) 1 and 2; retinoic acid-inducible gene (RIG)-I; interleukins (IL)-6, -10, and -12; interferon (IFN)-gamma; and tumor necrosis factor (TNF)-alpha mRNAs. We also compared the expression of immunoglobulins IgG, IgA, and IgM and the bacterial detection rate in the two groups.RESULTS:
TLR2-mediated expression of IL-6 mRNA, TLR4-mediated expression of IL-6 and IL-10 mRNA, TLR5-mediated expression of IL-6, IL-10, and TNF-alpha mRNA, TLR9-mediated expression of IL-6 mRNA, and NOD2-mediated expression of IL-6, IL-12, and TNF-alpha mRNA were significantly lower in obese than in non-obese children (P0.05).CONCLUSION:
Mean body mass index was higher and pattern-recognition receptor-mediated cytokine mRNA expression was lower in obese than in non-obese children with OME.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Otitis
/
Otitis Media
/
Bacteria
/
Otitis Media with Effusion
/
Immunoglobulin A
/
Immunoglobulin G
/
Immunoglobulin M
/
Immunoglobulins
/
RNA, Messenger
/
Body Mass Index
Limits:
Child
/
Humans
Language:
English
Journal:
Clinical and Experimental Otorhinolaryngology
Year:
2014
Type:
Article
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