Interferon therapy after curative surgical intervention to improve prognosis in patients with hepatitis C-related hepatocellular carcinoma: a Meta-analysis / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
;
(12): 805-809, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-505217
ABSTRACT
Objective To evaluate the effects of interferon therapy after curative surgical intervention on improving prognosis of patients with hepatitis C-related hepatocellular carcinoma (HCC).Methods We searched randomized clinical trials from 1990 to 2015 on interferon therapy after curative surgical intervention in patients with hepatitis C-related HCC from the Cochrane Library,the Cochrane Database of Systematic Reviews,MEDLINE and Embase.A Meta-analysis was carried out using Revman 5.Results There were 7 studies included in this research.The results showed that interferon therapy after curative surgical intervention in patients with hepatitis C-related HCC reduced the recurrence rate of HCC at 3 years (RR =0.84,95% CI 0.73 ~0.97,P <0.05).The therapy could not improve the 3-year survival rate in these patients (RR =1.04,95% CI 0.90 ~ 1.21,P > 0.05).Stratified subgroup analyses showed interferon therapy after liver resection reduced the recurrence rate (RR =0.62,95 % CI 0.39 ~ 1.00,P =0.05).For patients with tumors less than 3 cm,interferon therapy reduced the recurrence rate (RR =0.82,95% CI 0.69 ~ 0.98,P < 0.05).Conclusion Interferon therapy after curative surgical intervention improved prognosis in patients with hepatitis C-related HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Prognostic study
/
Systematic reviews
Language:
Chinese
Journal:
Chinese Journal of Hepatobiliary Surgery
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS