Parathyroid protection and identification by carbon nanoparticles suspension during total thyroidectomy / 中华普通外科杂志

ABSTRACT

Objective To evaluate carbon nanoparticles suspension in protection and identification of parathyroid in total thyroidectomy for thyroid papillocarcinoma.Methods This retrospective analysis included the clinical and pathological data of 97 patients from January 2014 to December 2014,52 cases injected carbon nanoparticles suspension (the test group).Serum calcium and parathyroid hormone (PTH) were measured preoperatively and on lst,3rd,7th day and one month postoperatively.Results Incidental parathyroidectomy occurred in 1 case (1.9％,1/52) in test group and in 7 cases (15.6％,7/45) in control group(P ＜0.05).The mean numbers of parathyroid glands identified intraoperatively were 3.1 ± 0.4/case and 2.6 ± 0.3/case respectively (P ＜ 0.05).The occurrence of temporary PTH hypofunction was 19.2％ (10/52) and 42.2％ (19/45) respectively (P ＜ 0.05).Also,test group had a higher level of PTH on postoperative day 1,3,7 and one month (P ＜ 0.05).Conclusions Carbon nanoparticles suspension significantly improved the identification of parathyroid gland during thyroid cancer surgery and reduced the risk of incidental parathyroid ectomy in total thyroidectomy.