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Correlation between heteroplasmy level of the 5178C>A mutation in the ND2 gene of mitochondria DNA and essential hypertension in middle-aged and elderly adults / 中华老年医学杂志
Chinese Journal of Geriatrics ; (12): 141-145, 2017.
Article in Chinese | WPRIM | ID: wpr-505467
ABSTRACT
Objectives To explore the correlation between the heteroplasmy level of mt5178C>A mutation in ND2 gene of mitochondria DNA and essential hypertension(EH)in middle-aged and elderly adults.Methods EH patients and normotensive controls were recruited consecutively from 2014-2015 from general population.Demographics,clinical characteristics and blood leukocytes were collected.The mt5178C>A mutation heteroplasmy level was quantified by the rapid and sensitive realtime polymerase chain reaction(PCR) method for each participant.Results A total of 108 EH patients and 109 controls were recruited.The mt5178C>A mutation heteroplasmy level was(42 ± 11%)in EH patients and (54± 13)% in control subjects,with statistically significant difference between the two groups(P<0.01).Using a two-step cluster analysis,the mt5178C>A heteroplasmy level exceeding 44% was associated with a decreased risk of EH(OR=0.18,95%,CI0.10-0.31,P<0.01).Correlation analysis showed mt5178C> A heteroplasmy level was significantly negatively correlated with both systolic blood pressure (r =-0.38,P< 0.001) and diastolic blood pressure (r =-0.49,P< 0.01)in 109 controls.Logistic regression analysis demonstrated that in single-factor analysis,mt5178C > A heteroplasmy level (OR =0.82,95 % CI0.77 0.87,P < 0.01) was protective factor for EH,however,BMI(OR=1.30,95%CI1.12-1.45,P<0.01),total cholesterol(OR=2.13,95%CI1.39-3.28,P=0.00),triglyceride(OR=7.62,95%CI3.45-16.84,P<0.01)and blood urea nitrogen(OR =1.35,95 % CI,P =0.03) were risk factors for EH.And a multiple logistic regression analysis showed that mt5178C> A heteroplasmy level (OR =0.83,95 % CI0.78-0.89,P< 0.01) was independent protective factor for E H,however,only total cholesterol (OR =2.17,95 % CI1.58-2.98,P =0.02) and low density lipoprotein cholesterol (OR =0.06,95% CI0.01-0.83,P =0.04) were independent risk factors for EH,and the P at critical 0.05 value.Conclusions Mitochondrial ND2 gene 5178C> A mutation heteroplasmy level exerts protective role against EH in middle-aged and elderly adults in Chinese population.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2017 Type: Article