Meta-analysis of split-dose and single-dose of polyethylene glycols for morning colonoscopy / 中华消化内镜杂志

ABSTRACT

Objective To evaluate the performance of split-dosed polyethylene(PEG) for colonoscopy preparation.Methods Split-dose means that 1-3 L of PEG is taken in the afternoon or evening before examination and the remains in the next morning.And single-dose refers to all PEG is taken in the evening before ex-amination.A meta-analysis was conducted to compare bowel preparation quality,adenoma detection rate and patients' acceptance between groups.Results Ten randomized controlled trials were included into this study with 3 222 participants(1 481 in split-dose group and 1 741 in single-dose group).Split-dose group had higher rate of satisfactory bowel preparation(OR=3.37,95％CI2.37-4.79),and so did the subgroup of 2～ 3 L PEG (OR =3.88,95％ CI2.39-6.29).Split-dose group did not improve adenoma detection rate significantly (OR =0.94,95％ CI0.71-1.24),but reported less adverse events such as nausea (OR =0.56,95％ CI0.42-0.74)and vomiting(OR=0.51,95％CI0.30-0.88).Conclusion Split-dosed PEG provides better colon cleansing with higher patient compliance,but does not improve detection rate of adenoma.