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Effects of curcumin on pulmonary functions and the expression of TGF-β1 and NF-κB of paraquat-induced pulmonary fibrosis of rats / 中华急诊医学杂志
Article in Zh | WPRIM | ID: wpr-505721
Responsible library: WPRO
ABSTRACT
Objective To discuss the effects and the possible mechanismof curcumin on pulmonary functions and expression of TGF-β1 and NF-κB in paraquat-induced pulmonary fibrosis of rats.Methods SPF Wistar rats were randomly (random number) divided into three groups:paraquat-poisoned group (PQ group,with PQ 50 mg/kg by gavage),Curcumin-treatment group (PC group after 30,with curcumin (200 mg/kg) by intraperitoneal injection),and Blank group (B group,with same volume of sterile saline at the same time).After 14 d,the lung function of rats was observed,and the expression of TGF-β1 and NF-κB protein were detected by immunohistochemistry.Results The survival rates of mice significant difference in the PC and PQ groups with (70.83% vs.41.67%,P <0.05).Compared with the B group,lung function index (Te,PIF,PEF,EF50,TV,F) of PQ group significantly decreased (P < 0.05,P < 0.01).Compared with the PQ group,lung function index (Te,PEF,TV,F) of PC group significantly increased (P < 0.05 or P < 0.01).There are some expression of lung tissues of rats with TGF-β1,NF-κB in B group.Compared with B group,PQ group significantly enhanced (P <0.01or P <0.05).Compared with the PQ,PC group significantly decreased (P < 0.01 or P < 0.05).Conclusions Curcumin can relieve paraquat-induced pulmonary fibrosis by inhibiting the over expression of TGF-β1,NF-κB in lung tissue of rats.
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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Emergency Medicine Year: 2017 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Emergency Medicine Year: 2017 Type: Article