Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 205-208, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-505832
ABSTRACT
The reversed pH gradient across the cell membrane on account of intracellular alkalinization and extracellular acidosis is an importart characteristic of tumor microenvironment.Sodium hydrogen exchanger isoform 1 (NHE1) is ubiquitously expressed at the plasma membrane of many types of cells,which plays a critical role in intracellular pH and cell volume homeostasis.NHE1 plays an important role in the regulation of tumor microenvironment and involves in tumor migration and invasion,which may be a potential new target in anti-cancer therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2017
Type:
Article
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