Correlation of AS160 hyperphosphorylation and 18 F-FDG uptaking in invasive breast cancer / 国际肿瘤学杂志
Journal of International Oncology
; (12): 173-176, 2017.
Article
in Zh
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| ID: wpr-505917
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ABSTRACT
Objective To investigate the correlation between AS160 hyperphosphorylation and 18Ffluorodeoxyglucose (18F-FDG) uptaking in invasive breast cancer.Methods Thirty-nine primary breast caner patients received PET/CT scan before operation and their maximum standard uptake values (SUVmax) were recorded.The levels of p-AS160 (Thr642) were detected using immunohistochemical method in breast cancer tissues.The association between p-AS160 (Thr642) levels and SUVmax was assessed using the Spearman nonparametric test.Results The 18F-FDG uptake of tumors of the 39 patients with primary breast caner was 6.1 ± 2.7 (SUVmax).There was one false negative case in PET/CT scan imaging,compared with postoperative pathologic result.The positive rate of p-AS160 (Thr642) was 76.9%,and it was positively correlated with SUVmax (r =0.672,P < 0.001).Conclusion AS160 plays a significant role in the glucose metablism of breast cancer tissues and its hyperphosphorylation may contribute to the increased uptaking of glucose in patients with breast cancer.
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Language:
Zh
Journal:
Journal of International Oncology
Year:
2017
Type:
Article