Observation of the effect of pregabalin capsules in the treatment of shoulder hand syndrome after stroke / 中国基层医药

ABSTRACT

Objective To investigate the effect of pregabalin capsules in the treatment of shoulder hand syndrome after stroke.Methods 90 patients with shoulder hand syndrome after stroke were divided into observation group and control group according to random number table method,45 cases in each group.Rehabilitation training and acupuncture treatment were used in the control group,and on the basis of the control group,the observation group used pregabalin capsules treatment,initial dose 75mg/times,oral,2 times/d.After 2 weeks,the dose was changed to 150mg/times,oral,2 timnes/d.Maintenance therapy for 8 weeks.The overall efficacy and pain degree before and after treatment,upper limb function of the two groups were compared.Results After treatment,the VAS scores of the two groups were significantly decreased,and the FMA scores were significantly increased,the differences were statistically significant compared with before treatment(t =17.353,15.777,12.001,10.432,all P ＜ 0.05).And the improvement degrees of VAS score and FMA score of the observation group were significantly better than those of the control group [(18.3 ± 12.9) points vs.(29.8 ± 12.1) points,(53.1 ± 9.2) points vs.(42.3 ± 8.9) points],the differences were statistically significant(t =3.294,4.672,all P ＜ 0.05).The total effective rate of the observation group was 93.3％,which was significantly higher than 77.8％ of the control group,the difference was statistically significant (x2 =4.406,P ＜ 0.05).Conclusion In the treatment of shoulder hand syndrome after stroke,pregabalin capsules has good effect.