Fibrillary glomerulonephritis combined with chronic inflammatory demyelinating polyneuropathy
Kidney Research and Clinical Practice
;
: 117-119, 2015.
Article
in English
| WPRIM
| ID: wpr-50605
ABSTRACT
A 58-yr-old man presented with leg edema and subacute weakness of his bilateral lower extremities. Urinary and serum immunoelectrophoresis revealed the presence of lambda-type Bence Jones proteins. He was ultimately diagnosed with monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy specimen showed fibrillary glomerulonephritis (FGN), which was randomly arranged as 12-20 m nonbranching fibrils in the basement membranes. Immunofluorescence studies were negative for immunoglobulin (Ig)G, IgM, IgA, C3, and kappa light chains in the capillary walls and mesangial areas. A Congo red stain for amyloid was negative. Electromyography and nerve conduction velocity examinations results were compatible with the presence of demyelinating polyneuropathy. This case showed a rare combination of FGN, without Ig deposition, and MGUS combined with chronic inflammatory demyelinating polyneuropathy (CIDP).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraproteinemias
/
Polyneuropathies
/
Basement Membrane
/
Biopsy
/
Monoclonal Gammopathy of Undetermined Significance
/
Bence Jones Protein
/
Immunoglobulin A
/
Immunoglobulin M
/
Immunoglobulins
/
Capillaries
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2015
Type:
Article
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