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Does hypokalemia contribute to acute kidney injury in chronic laxative abuse?
Kidney Research and Clinical Practice ; : 109-112, 2015.
Article in English | WPRIM | ID: wpr-50607
ABSTRACT
Prolonged hypokalemia from chronic laxative abuse is recognized as the cause of chronic tubulointerstitial disease, known as "hypokalemic nephropathy," but it is not clear whether it contributes to acute kidney injury (AKI). A 42-year-old woman with a history of chronic kidney disease as a result of chronic laxative abuse from a purging type of anorexia nervosa (AN-P), developed an anuric AKI requiring hemodialysis and a mild AKI 2 months later. Both episodes of AKI involved severe to moderate hypokalemia (1.2 and 2.7 mmol/L, respectively), volume depletion, and mild rhabdomyolysis. The histologic findings of the first AKI revealed the remnants of acute tubular necrosis with advanced chronic tubulointerstitial nephritis and ischemic glomerular injury. Along with these observations, the intertwined relationship among precipitants of recurrent AKI in AN-P is discussed, and then we postulate a contributory role of hypokalemia involved in the pathophysiology of the renal ischemia-induced AKI.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rhabdomyolysis / Anorexia Nervosa / Renal Dialysis / Renal Insufficiency, Chronic / Acute Kidney Injury / Hypokalemia / Necrosis / Nephritis, Interstitial Limits: Adult / Female / Humans Language: English Journal: Kidney Research and Clinical Practice Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rhabdomyolysis / Anorexia Nervosa / Renal Dialysis / Renal Insufficiency, Chronic / Acute Kidney Injury / Hypokalemia / Necrosis / Nephritis, Interstitial Limits: Adult / Female / Humans Language: English Journal: Kidney Research and Clinical Practice Year: 2015 Type: Article