Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold
Kidney Research and Clinical Practice
;
: 76-82, 2015.
Article
in English
| WPRIM
| ID: wpr-50612
ABSTRACT
Cardiovascular complications dominate the landscape of chronic kidney diseases (CKD). Endothelial cell dysfunction (ECD) is a well-known culprit of cardiovascular morbidity and it develops in CKD with remarkable frequency. This brief overview of ECD in CKD scans two decades of studies performed in my laboratory, from genetic analyses to proteomic and metabolomics screens. I provide a detailed description of findings related to the premature senescence of endothelial cells, cell transition from the endothelial to mesenchymal phenotype, and stages of development of ECD. Clinical utility of some of these findings is illustrated with data on laser-Doppler flowmetry and imaging in patients with CKD. Some currently available and emerging therapeutic options for the management of ECD are briefly presented.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Aging
/
Retrospective Studies
/
Laser-Doppler Flowmetry
/
Endothelial Cells
/
Renal Insufficiency, Chronic
/
Metabolomics
Type of study:
Etiology study
/
Observational study
Limits:
Humans
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2015
Type:
Article
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