Changes of amplitude integrated electroencephalogram during brain development in premature / 中华实用儿科临床杂志

ABSTRACT

Objective To explore the changes of amplitude integrated electroencephalogram (aEEG) during brain development in premature.Methods One hundred and forty-eight premature (gestational age 28-36 weeks) were selected.According to their gestational ages,148 premature were divided into 28-30 weeks group(40 cases),with 21 male,19 female;＞30-33 weeks group (49 cases),with 25 male,24 female;＞33-36 weeks group (59 cases),33 male,26 female.At the same time,40 cases of gestational age 37-40 weeks full-term newborns were selected as control group,with 23 male,17 female.Olympic CFM 6000 cerebral function monitor(produced by the American Natus company) was used to detect the changes of their aEEG,and analysis of the changes of aEEG were conducted.The first monitor was performed 3 days after birth,then once a week,monitoring for 2 hours each time,till the premature were discharged from hospital.The average of the monitoring data was obtained as a result for the analysis,and data analysis was conducted by using SAS 9.0 statistical software.Results The sleep-wake cycle continuity voltage positive rate and cycle occurrence rate of the 28-30 weeks,＞ 30-33 weeks,＞ 33-36 weeks premature were significantly lower than those of the 37-40 weeks full-term newborns (all P ＜ 0.05).The 28-30 weeks,＞ 30-33 weeks,＞ 33-36 weeks premature spectrun lower bound voltage value of quiet sleep cycle and activity sleep cycle were significantly lower than those of the 37-40 weeks full-term newborns (all P ＜ 0.05).The 28-30 weeks,＞ 30-33 weeks,＞ 33-36 weeks premature spectrum width of quiet sleep cycle and activity sleep cycle were significantly wider than the 37-40 weeks full-term newborns (F =13.444,11.982,all P ＜ 0.05).The 28-30 weeks,＞ 30-33 weeks,＞ 33-36 weeks premature total duration of sleep cycle were significantly higher than the 37-40 weeks full-term newborns (F =12.451,P ＜ 0.05).Conclusions With the increase of gestational age,premature brain development becomes gradually mature,and aEEG can reflect the degree of premature brain development to some extent.