Research advances in multifocal hepatocellular carcinoma / 中华肝胆外科杂志

ABSTRACT

Based on the pathogenetic occurrence of the tumor,multinodular hepatocellular carcinoma can be classified into multicentric occurrence and intrahepatic metastasis.Different diagnostic strategies from genomics,transcriptomics and proteomics can be used to define the clonal origin of tumors and provide advisable method to cure the disease.Pathomorphological test wasgold standard in cancer diagnosis at one time.Currently,from the respect of molecular diagnosis,including HBV DNA intergration,p53 mutation,selective X chromosome inactivation,loss of heteozygosity of chromosomal DNA,mtDNA-Loop,transcriptional sequence,and comparative proteomics,we could accurately differentiate the clonal origin of tumors.Intrahepatic metastasis was demonstrated with a high early recurrence rate and low survival rate comparing to the multicentric occurrence from the review of the previous study.