Management of Acute Submacular Hemorrhage with Intravitreal Injection of Tenecteplase, Anti-vascular Endothelial Growth Factor and Gas
Korean Journal of Ophthalmology
;
: 192-197, 2016.
Article
in English
| WPRIM
| ID: wpr-50643
ABSTRACT
PURPOSE:
To evaluate the visual and anatomical outcomes for neovascular age-related macular degeneration with submacular hemorrhage after intravitreal injections of tenecteplase (TNK), anti-vascular endothelial growth factor (VEGF) and expansile gas.METHODS:
This study was a retrospective clinical case series following 25 eyes of 25 patients. All patients received a triple injection using 0.05 mL TNK (50 µg), 0.05 mL anti-VEGF and 0.3 mL of perfluoropropane gas. Retreatment with anti-VEGF was performed as needed. Preoperative and postoperative best-corrected visual acuity and central retinal thickness were analyzed.RESULTS:
The mean logarithm of the minimum angle of resolution of best-corrected visual acuity improved significantly from 1.09 ± 0.77 at baseline to 0.52 ± 0.60 at 12 months (p < 0.001). The mean central retinal thickness also improved significantly from 545 ± 156 at baseline to 266 ± 107 at 12 months (p < 0.001). A visual improvement of 0.3 logarithm of the minimum angle of resolution unit or more was achieved in 15 eyes (60%). During the 12 postoperative months, an average of 4.04 intravitreal anti-VEGF injections was applied.CONCLUSIONS:
A triple injection of TNK, anti-VEGF, and a gas appears to be safe and effective for the treatment of submacular hemorrhage secondary to neovascular age-related macular degeneration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retinal Hemorrhage
/
Fluorescein Angiography
/
Visual Acuity
/
Acute Disease
/
Retrospective Studies
/
Follow-Up Studies
/
Treatment Outcome
/
Tissue Plasminogen Activator
/
Vascular Endothelial Growth Factor A
/
Tomography, Optical Coherence
Type of study:
Observational study
/
Prognostic study
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2016
Type:
Article
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