The research advances of zinc transporter LIV-1 in esophageal squamous cell carcinoma / 实用肿瘤学杂志

ABSTRACT

LIV-1(SLC39A6/ZIP6),primarily located on the cell membrane ,is one of the LZT subfami-ly members among the zinc transportprotein family .It possess six to eight transmembrane spanning domains ,with regions of concentrated histidine residues ,which has been shown to participate in the process of embryonic devel-opment as well as the growth and proliferation of tumors .It has been clearly established that LIV -1 played an important role in the development of esophageal squamous cell carcinoma and its overexpression ,which turned out to be a negative correlation upon the cancer′s prognosis has been verified to be a potent therapeutic target .Here-in,the advances of zinc transporter LIV -1 and the potential significance of the transporter to esophageal squa-mous cell carcinoma are reviewed .