Clinicopathological characteristics and prognosis analysis of Uygurs and Hans signet ring cell carcinoma of Xinjiang / 实用医学杂志

ABSTRACT

Objective To analyze the differences in the clinical characteristics,pathological characteristics and survival between Uygurs and Hans gastric signet ring cell carcinoma (SRC) ,and the clinicopathological data of Uygurs SRC were analyzed by COX proportional hazard model. Methods 120 clinical data of patients with gastric cancer from January 2009 to January 2015 were analyzed. The patients were divided into Uygurs and Hans gastric signet ring cell carcinoma (SRC). The gender,age,tumor location,size,depth of invasion,lymph node and distant metastasis,the median time to progression,survival rate after radical operation of two groups were analyzed. The clinicopathological data of 57 cases with Uygurs SRC were analyzed ,multivariate analysis was done by COX proportional hazard model. Results In Uygurs,the age,lymphnode metastasis,distant metastasis and the median time to progression were statistically different from Hans (P 0.05). Conclusion Compared with Uygurs,Hans has early age of onset,more lymph node and distant metastasis,and is prone to progression. Also,age,lymphnode metastasis and depth of invasion serve as independently prognostic indexes of Uygurs gastric SRC by COX proportional hazard model.