Research progress in epigenetic aberrant in classic Hodgkin lymphoma / 实用肿瘤学杂志
Practical Oncology Journal
;
(6): 73-77, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-507133
ABSTRACT
The malignant phenotype of classical Hodgkin lymphoma ( cHL) is partly maintained by epige-netic aberrant ,of which consisted mainly abnormal histone methylation and deacetylation .Progress has been made in clinical trials related to the histone deacetylases inhibitors ( HDACis) in cHL.There is a close association noted between the epigenetic aberrants and the immune escape in cHL .DNA methyltransferase ( DNMT) inhibitors, HDACis and immune checkpoint blockade have shown synergistic effects .Further study to improve the cure rate in cHL by combination strategy is of significant importance .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Practical Oncology Journal
Year:
2017
Type:
Article
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