Mechanisms involved in liver metastasis of breast cancer / 实用肿瘤学杂志

ABSTRACT

Liver is the common metastatic site of breast cancer .The process of liver metastasis consists of multiple steps and involves various factors from breast cancer cells and the liver micro -environment .In this re-view,we reviewed the molecular(including the connection of proteins ,protein kinases,miRNAs),signal transduc-tion pathways(including CXCL12-CXCR4 axis,Wnt/beta-catenin signaling pathway,AF1q/TCF7/CD44 regu-latory axis,laminin receptor/Akt/ERK signaling pathway,leptin/ERK/IL-8 signaling pathway)and the influen-cing factors(including hypoxia inducible factors,tumor-associated fibroblasts,adipose tissue matrix stem cells, metalloproteinases,selective ligands,inflammatory cell infiltration)associated with the liver micro -environment in breast cancer .