Relationship between serum levels of BDNF,IL-6 and Hcy with cognitive function impairment in patients with first episode schizophrenia / 国际检验医学杂志

ABSTRACT

Objective To explore the relationship between the levels of serum BDNF,IL-6 and Hcy with cognitive impairment in the patients with first episode schizophrenia.Methods One hundred and thirty-five patients with schizophrenia(patients group)and 130 mental healthy volunteers (control group)in our hospital from January 2015 to January 2016 were selected as the research sub-jects.The levels of IL-6 and BDNF were detected by adopting the enzyme linked immunosorbent assay (ELISA)and Hcy level was detected by using the circulating enzymatic method.The mental symptoms were evaluated by the positive and negative symptom rat-ing scale (PANSS),cognitive function was evaluated by the Wisconsin Card Sorting Test (WCST)and their relationship was ana-lyzed.Results The BDNF level in the patients group was significantly lower than that in the control group,while the Hcy and IL-6 levels were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The WCST errors response number,persistent errors number and total responses number in the patients group were significantly higher than those in the control group,while the complete classification number and correct response number were significantly lower than those in the control group,the differences were statistically significant (P<0.05).The levels of BDNF,IL-6 and Hcy had significant cor-relation with the WCST total responses number,persistent errors number,errors response number and complete classification num-ber.Conclusion The levels of serum Hcy,IL-6 and BDNF in the patients with first episode schizophrenia have a certain relation with the mental symptoms and cognitive function,which demonstrates the existence of nerve-humor-immune regulation network regulation mechanism in a certain degree and plays a synergic action in the occurrence and development of schizophrenia.