Preparation and Properties of Mesalazine β-Cyclodextrin Inclusion Compound / 中国药师
China Pharmacist
;
(12): 266-270, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-507504
ABSTRACT
Objective:
To prepare mesalazineβ-cyclodextrin inclusion compound and observe its properties.Methods:
The struc-ture was characterized by UV, IR and DSC. The inclusion process of mesalazine andβ-cyclodextrin was simulated using molecular doc-king technique. The solubility and dissolution of inclusion compound were determined.Results:
UV, IR and DSC were used to deter-mine the formation of inclusion complex. The inclusion ratio was 1 1 and the phase solubility diagram was AL type. The solubility of inclusion compound in deionized water (25 ℃, pH 7. 0) was 7. 8 mg·ml-1 . The preparation of mesalazine β-cyclodextrin inclusion compound could significantly increase the dissolution rate and solubility of mesalazine.Conclusion:
The prepared mesalazineβ-cyclo-dextrin inclusion compound can obviously improve the poor water solubility and dissolution of mesalazine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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