Concentration Screening and Antimicrobial Effectiveness of Antimicrobial Preservative for Fluconazole Eye Drop / 中国药师
China Pharmacist
;
(12): 362-364, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-507553
ABSTRACT
Objective:
To explore the reasonable amount of bacteriostatis agent in fluconazole eye drop.Methods:
According to the method of bacteriostatis effect test in 2015 edition of Chinese Pharmacopoeia (ChP), and Staphyococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candia albicans and Aspergillus niger as the test strains, the bacteriostatis effect of fluconazole eye drop containing 5%, 1%, 0. 3% and 0. 1% benzalkonium chloride was determined.Results:
The bacteriostatis effects of fluconazole eye drop containing 5%, 1% and 0. 3% benzalkonium chloride on the five species of tested bacteria complied with the regulations of ChP. The bacteriostatis effects of 0. 1% benzalkonium chloride on Pseudomonas aeruginosa didn't meet the requirements, therefore, 0. 3%was the minimum inhibitory concentration ( MIC) of benzalkonium chloride.Conclusion:
The best inhibitory concentration of benza-lkonium chloride is 1%.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Screening study
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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