Mechanisms of Diabetogenic Action of Statins / 中国药师
China Pharmacist
;
(12): 337-339, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-507563
ABSTRACT
Objective:
To alarm the effect of statins on blood glucose, and provide evidence for the rational use of statins in clin-ics.Methods:
The recent articles on the effects and potential mechanisms of diabetogenic action of statins were reviewed and summa-rized. Results andConclusion:
Stains, especially lipophilic stains, could increase blood glucose via multiple pathways to induce dia-betes. The potential mechanisms included inhibiting L-type calcium channel, increasing the uptake of plasma-derived LDL-C, inhibi-ting synthesis of ATP and Coenzyme Q10, inhibiting the expression of glucose transporter 4 and inducingβ-cell inflammation, oxidation and apoptosis. Blood glucose should be monitored and adjusted timely when statins are used in clinics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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