Clinical Efficacy of α-Lipoic Acid versus Epalrestat in the Treatment of Diabetic Peripheral Neuropathy:A Systematic Review / 中国药房
China Pharmacy
;
(12): 786-790, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-507584
ABSTRACT
OBJECTIVE:
To systematically review the efficacy of α-lipoic acid versus epalrestat in the treatment of diabetic pe-ripheral neuropathy(DPN),and provide evidence-based reference for clinic.METHODS:
Retrieved from CJFD,CBM,VIP,Wan-fang Database and PubMed,randomized controlled trials(RCT)about α-lipoic acid versus epalrestat in the treatment of DPN were collected,and the study was screened by inclusion and exclusion criteria. Meta-analysis was performed by using Rev Man 5.3 soft-ware after data extraction and quality evaluation by Cochrane software.RESULTS:
Totally 6 RCTs were enrolled,involving 408 pa-tients. Results of Meta-analysis showed,compared with epalrestat,there were no significant differences in the total effective rate [RR=0.98,95%Cl(0.84,1.15),P=0.81],motor nerve conduction velocity [median nerveMD=1.02,95%Cl(-1.10,3.14),P=0.34;common peroneal nerveMD=0.23,95%Cl(-1.11,1.58),P=0.73] and sensory nerve conduction velocity [median nerveMD=1.10,95%Cl(-0.39,2.59),P=0.15;common peroneal nerveMD=0.95,95%Cl(-1.47,3.36),P=0.44] in α-lipoic acid group.CONCLUSIONS:
The efficacy of α-lipoic acid is similar to epalrestat in the treatment of DPN,as well as the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve or common peroneal nerve.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Systematic reviews
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Type:
Article
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