Effect of green tea polyphenols on uric acid level in potassium oxonate-induced hyperuricemic mice and mechanism / 中国药理学通报

ABSTRACT

Aim To investigate the effect of green tea polyphenols(GTP)on serum level of uric acid in potas-sium oxonate (PO)-induced hyperuricemic mice,and explore the potential mechanism.Methods PO and GTP were intragastricly administered to mice for seven consecutive days.Uric acid level in serum was exam-ined.Meanwhile,activity and expressions of xanthine oxidase(XOD)in liver were tested.In additon,ex-pressions of urate transporters including urate-anion transporter (URAT ) 1 , organic anion transporter (OAT)1 and 3 in kidney were analyzed.Results GTP significantly decreased the serum level of uric acid in PO-induced hyperuricemic mice.At the same time, GTP markedly reduced the activity and expression of XOD in liver of hyperuricemic mice.Finally,GTP markedly reduced the expression of URAT1 ,OAT1 and OAT3 in kidney of hyperuricemic mice.Conclusion GTP has the effect of lowering uric acid in PO-induced hyperuricemic mice through both decreasing the uric acid production and increasing uric acid excretion.