Impact of Water Infusion Colonoscopy on Abdominal Pain and Inflammatory Response in Elderly Patients / 胃肠病学

ABSTRACT

Background:Colonoscopy is difficult in elderly patients and is accompanied by more frequent abdominal pain and tissue injury. Aims:To investigate the impact of water infusion colonoscopy on abdominal pain and inflammatory response in elderly patients. Methods:Forty elderly patients requiring colonoscopy were enrolled from Jan. 2014 to Jun. 2016 at the Nanyang Second People’s Hospital and randomly allocated into two groups:colonoscopy with traditional air insufflation and colonoscopy with water infusion instead of air insufflation for cecal intubation. Times of cecal intubation and withdrawal were recorded;visual analogue scale( VAS)was used to assess the severity of abdominal pain;and serum levels of three inflammatory indices,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)were determined by ELISA before and after the procedure. Results:VAS score at colonoscopy in water infusion group was significantly lower than that in air insufflation group(P﹤0. 05),however,times of cecal intubation and withdrawal were not significantly different between the two groups(P﹥0. 05). Before the procedure,serum levels of inflammatory indices were similar between air insufflation group and water infusion group(P﹥0. 05);0,6 and 24 hours after the procedure, serum levels of TNF-α,IL-6 and CRP in air insufflation group were significantly increased(P﹤0. 05)and higher than those in water infusion group at the same time points(P﹤0. 05). These inflammatory indices were recovered more rapidly in water infusion group than in air insufflation group. Conclusions:For elderly patients,colonoscopy with water infusion might ameliorate abdominal pain and inhibit systemic inflammatory response effectively.