Therapeutic effect of Acarbose in combination with other hypoglycemic drugs / 中国糖尿病杂志

ABSTRACT

[Summary] Acarbose is a kind of α-glucosidases that binds competitively to the complex oligosaccharide at the brush border of the small intestine,thus delaying the breakdown of sucrose and starch and the absorption of glucose and fructose. During the exacerbation of T2DM,Acarbose mono therapy gradually failed to control blood glucose,and should be combined with other oral hypoglycemic agents,such as Metformin,insulin secretagogues,dipeptidyl peptidase-4 (DPP-4)inhibitors,glucagon-like peptide (GLP-1),sodium-glucose cotransporter 2 (SGLT-2)inhibitors or insulin. Here we reviewed recent researches about the therapeutic effect of Acarbose in combination with other anti-diabetic agents.