Research progress of strontium-doped biomedical titanium alloys / 中国组织工程研究

ABSTRACT

BACKGROUND:Surface modification of titanium surface to improve its biological activity is the research hotspot. Strontium-doped coating is considered to be an effective approach to promote the implant osseointegration. OBJECTIVE:To introduce the research progress of strontium-modified biomedical titanium al oys.METHODS:Articles related to the medical titanium al oys modified with strontium published from January 2000 to April 2016 were retrieved from CNKI and PubMed databases. The keywords were“titanium (Ti), strontium (Sr), bone, osteogenic”in Chinese and English, respectively. RESULTS AND CONCLUSION:Titanium al oys have been widely used in bone implantation because of their good biocompatibility and similar elasticity modulus with human bones. However, pure titanium al oys have poor bioactivity which leads to weak bone-implant contact. Surface modification is a good approach to enhance implant osseointegration. Sr-doped surface treatment can promote new bone formation and osseointegration. Most of the studies about Sr-doped modification are ongoing at the extracorporeal and animal experiment stage;therefore, further investigation is required to seek rapid, stable, available, safe and effective methods.