Effects of warfarin on coagulation function and hemorrheology index in atrial fibrillation / 中国生化药物杂志

ABSTRACT

Objective To investigate the effect of warfarin on coagulation function and hemorheology index in patients with atrial fibrillation. Methods Retrospective a total of 90 patients with atrial fibrillation who underwent anticoagulant therapy from June 2014 to December 2015 in The Fourth People's Hospital of Wenling City were randomly divided into the control group and the warfarin group with 45 cases in each group.The patients in the control group were treated with aspirin, the patients in the warfarin group were treated with warfarin.The indexes of coagulation function and hemorheology were measured before and after treatment, and the effects of warfarin on patients with atrial fibrillation were observed and analyzed. Results After treatment, there was no significant change in coagulation function in the control group, the thrombin time (PT), thrombin time (TT), and partially activated thrombin time (APTT) of warfarin group were significantly increased, the difference was statistically significant (P<0.05), and the coagulation function of warfarin group was significantly higher than that of the control group, the difference was statistically significant (P<0.05).The plasma viscosity, red blood cell index, high shear whole blood viscosity, low shear whole blood viscosity and fibrinogen (FIB) were significantly lower in the two groups, the difference was statistically significant (P<0.05), and the high shear whole blood viscosity, low shear whole blood viscosity and FIB of warfarin group were significantly lower than those of the control group, the difference was statistically significant ( P <0.05 ). Conclusion Warfarin has a potent effect on platelet activation, which can produce anticoagulation by adjusting coagulation function, platelet parameters and hemorheology in patients with atrial fibrillation.