Effect of ultrasound-guided serratus plane block on efficacy of postoperative analgesia in patients under-going radical mastectomy / 临床麻醉学杂志

ABSTRACT

Objective To investigate the effect of ultrasound-guided serratus plane block on ef-ficacy of postoperative analgesia in patients undergoing radical mastectomy.Methods Forty ASA physical status Ⅰ or Ⅱ patients aged 45-65 years scheduled for radical mastectomy under general an-esthesia were randomly divided into two groups (n = 20 each)SP block group (group SP)and control group (group C).After induction of anesthesia,ultrasound-guided homolateral SP block were performed,and 0.375% ropivacaine 20 ml was injected in group SP,while the equal volume of normal saline was used instead in group C.The patients received patient-controlled intravenous analgesia (PCIA)with sufentanil after operation in the two groups.The scores of prince henry pain scale (PHPS)were evaluated at 2,4,8,12 and 24 h after operation.The consumption of sufentanil, propofol and remifentanil were recorded,meantime the times of successfully delivered doses (D1)and attempts (D2 )within 24 h after operation were added up,calculating D1/D2.The adverse effects were also recorded.Results The scores of PHPS at postoperative 2 h [(1.3±0.4)scores vs.(3.0±0.5) scores],4 h [(1.4 ± 0.5 )scores vs.(2.9 ± 0.7 )scores],8 h [(1.7 ± 0.6 )scores vs.(2.7 ± 0.6 ) scores],and the consumption of sufentanil [(54±17)μg vs.(88±25)μg],remifentanil [(287±41)μg vs.(375±66)μg]were significantly lower in group SP than in group C,while D1/D2 (0.88 ±0.11 vs. 0.56±0.17)was higher (P <0.05).There were no adverse reactions in both groups.Conclusion Ultra-sound-guided SP block reduces the perioperative opioids consumption and enhances the efficacy of postopera-tive analgesia in patients undergoing radical mastectomy.