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Overview of complement-targeted therapy / 中国生化药物杂志
Chinese Journal of Biochemical Pharmaceutics ; (6): 7-10, 2016.
Article in Chinese | WPRIM | ID: wpr-508559
ABSTRACT
The complement system is a powerful effector arm of innate immunity, which have the roles in phagocytosis of foreign elements, solubilization of immune complexes, apoptotic cell clearance and enhance of humoral immune responses.Dysregulation of complement activity has been connected to various disease including infections, autoimmune diseases and cancers.These triggered a broad of candidates acting at complement activation are currently in clinical development.This review will provide an overview of complement system and related diseases , and update recent development in complement-targeted drug discovery.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Biochemical Pharmaceutics Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Biochemical Pharmaceutics Year: 2016 Type: Article