Analysis of atorvastatin and trimetazidine on CHD blood lipid level changes and angina improve / 中国生化药物杂志

ABSTRACT

Objective To investigate the effects of atorvastatin and trimetazidine treatment of coronary heart disease (CHD) effect and influence on blood lipid levels.Methods Selected 103 CHD patients treated in our hospital from March 2013 to January 2016, were randomly divided into observation group (n=57) and control group (n=46), the observation group was given atorvastatin combined with trimetazidinetreatment, control group was given trimetazidine treatment, compared the two groupstherapeutic, blood lipid levels etc.Results The curative effect of observation group was significantly better than that of the control group ( P <0.05 ) , markedly effective was 54.39%, effective was 38.60%; The observation group after treatment blood lipid levels were lower than before treatment ( P <0.05 ); The control group after treatmenttotal cholesterol ( TC ) and low density lipoprotein cholesterol (LDL-C) compared with before treatment decreased (P<0.05), and three glycerol (TG) and high density lipoprotein cholesterol ( HDL-C) difference had no statistical significant compared with before treatment;The observation group after treatment TC, TG, HDL-C and LDL-C were lower than the control group (P<0.05);Observation group after treatment the duration of exercise, induced angina pectoris attack time and ST segment down 1 mm time were (624.59 ±90.15)s, (470.29 ±44.20)s and (455.04 ±82.05)s, significantly longer than that in control group (P<0.05);Observation group after treatment superoxide dismutase (SOD) was (87.82 ±8.84)U/mL, significantly higher than that of the control group (P<0.05), and malondialdehyde (MDA)was (4.02 ±0.70)nmol/mL, was significantly lower than that of the control group (P<0.05).Conclusion Atorvastatin combined with trimetazidine treatment CHD curative effect is better, can reduce the level of blood lipid and oxidative stress, is worthy of clinical use.