The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder
Psychiatry Investigation
;
: 616-621, 2016.
Article
in English
| WPRIM
| ID: wpr-50901
ABSTRACT
OBJECTIVE:
The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma.METHODS:
The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F 18/43). The patients were divided into two groups patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q, 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all evaluated by the ELISA method.RESULTS:
Our evaluation revealed a diagnosis of PTSD in 51% (n=31) of victims. There was no significant difference between the groups with or without PTSD in terms of cortisol, GPx, SOD, coenzyme Q, and 8-OHdG levels. There was no correlation between CAPS scores and GPx, SOD, coenzyme Q, and 8-OHdG levels between patients with or without PTSD. In patients with PTSD, both cortisol and 8-OHdG levels decreased with increasing time after trauma, and there was no significant correlation with cortisol and 8-OHdG levels in patients without PTSD.CONCLUSION:
Although the present study did not find any difference between the groups in terms of 8-OHdG concentrations, the decreases in both cortisol and 8-OHdG levels with increasing time after trauma is considered to indicate a relationship between cortisol and DNA damage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sex Offenses
/
Stress Disorders, Post-Traumatic
/
Superoxide Dismutase
/
DNA Damage
/
DNA
/
Enzyme-Linked Immunosorbent Assay
/
Hydrocortisone
/
Ubiquinone
/
Oxidative Stress
/
Diagnosis
Type of study:
Diagnostic study
/
Qualitative research
Limits:
Adolescent
/
Child
/
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2016
Type:
Article
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