Transient receptor potential in tissue fibrosis / 国际药学研究杂志

ABSTRACT

Transient receptor potential(TRP)channels superfamily consists of a large number of nonselective cation chan?nels,which can be grouped into six subfamiliescanonical,vanilloid,melastatin,ankyrin,polycystic and mucolipin TRP channels. The majority of these TRP channels are expressed in different organs including respiratory airway,lung,kidney,heart,intestinal tract,stomach and liver. TRP channels can sense various stimuli including pressure,oxidative stress,lipid environment alterations, hypertrophic signals,and inflammation products. By integrating these stimuli and via Ca2+entry,TRP channels play main role in regu?lating cell functions such as contraction,proliferation,differentiation and cell death. TRP channels is involved in the pathophysiology of numerous cellular functions,and connected to cystic fibrosis,cardiac fibrosis,renal fibrosis,and liver fibrosis. This review mainly summarizes the involvement of TRP channels in tissue fibrosis.