MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2
Experimental & Molecular Medicine
;
: e112-2014.
Article
in English
| WPRIM
| ID: wpr-50915
ABSTRACT
MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast growth factor 2 (FGF2) was confirmed as a direct target of miR-152. FGF2 knockdown suppressed cell proliferation, colony formation, migration and invasion, whereas FGF2 overexpression partially reversed the suppressive effect of miR-152. Furthermore, the presence of miR-152 was inversely correlated with FGF2 in NSCLC tissues. Overall, this study demonstrated that miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gene Expression Regulation, Neoplastic
/
Cell Movement
/
Fibroblast Growth Factor 2
/
Carcinoma, Non-Small-Cell Lung
/
MicroRNAs
/
Cell Proliferation
/
Lung
/
Lung Neoplasms
/
Neoplasm Invasiveness
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2014
Type:
Article
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