Expression and clinical significance of TGF-β1,Smad-3 and Smad-7 in the serum of colorectal cancer patients / 安徽医科大学学报
Acta Universitatis Medicinalis Anhui
;
(6): 285-287, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-509586
ABSTRACT
Objective To provide clinical evidence for the relationship between epithelial-mesenchymal transition (EMT) and colorectal cancer(CRC) by detecting the expression of TGF-β, Smad-3 and Smad-7 in serum from CRC patients. Methods We detected the expression levels of TGF-β1 , Smad-3 and Smad-7 by ELISA method. Results The expression levels of TGF-β1 , Smad-3 were significantly higher and the Smad-7 was significantly lower in CRC patients than those in control group(P<0. 01). The expression levels of TGF-β1 and Smad-3 were signifi-cantly higher in Dukes D than those in Dukes B,C. The Smad-7 was significantly lower in Dukes D than that in Dukes B,C(P<0. 01). Conclusion TGF-β1 and Smad-3 and Smad-7 may play an important role in the develop-ment of CRC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Universitatis Medicinalis Anhui
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS