Progress of microRNA in chemoresistance in lung cancer / 肿瘤研究与临床

ABSTRACT

Lung cancer has become one of common malignant tumors, and an increasing mortality of lung cancer is mainly due to induction of resistance to chemotherapeutic agents. However, the molecular mechanism of drug resistance in lung cancer remains poorly understood. Many studies have shown that both overexpression of drug resistance genes and dysregulation of signal pathways are involved in the drug resistance. MicroRNAs (miRNAs), a class of endogenous non-coding small RNA molecules, are closely correlated with cell growth, apoptosis and signal transduction. Meanwhile, drug metabolism in vivo can also be regulated by miRNA. Moreover, miRNA also plays an important role in drug resistance of tumor cells. This paper will highlight the potential of miRNA as suppressors and biomarkers for chemoresistance and prognosis in lung cancer.